Details

Autor(en) / Beteiligte

• Do, Son Ngoc
• Dao, Co Xuan
• Nguyen, Tuan Anh
• Nguyen, My Ha
• Pham, Dung Thi
• Nguyen, Nga Thi
• Huynh, Dai Quang
• Hoang, Quoc Trong Ai
• Bui, Cuong Van
• Vu, Thang Dinh
• Bui, Ha Nhat
• Nguyen, Hung Tan
• Hoang, Hai Bui
• Le, Thuy Thi Phuong
• Nguyen, Lien Thi Bao
• Duong, Phuoc Thien
• Nguyen, Tuan Dang
• Le, Vuong Hung
• Pham, Giang Thi Tra
• Bui, Giang Thi Huong
• Bui, Tam Van
• Pham, Thao Thi Ngoc
• Nguyen, Chi Van
• Nguyen, Anh Dat
• Phua, Jason
• Li, Andrew
• Luong, Chinh Quoc

Titel

Sequential Organ Failure Assessment (SOFA) Score for predicting mortality in patients with sepsis in Vietnamese intensive care units: a multicentre, cross-sectional study

Ist Teil von

• BMJ open, 2023-03, Vol.13 (3), p.e064870-e064870

Ort / Verlag

England: British Medical Journal Publishing Group

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• ObjectivesTo compare the accuracy of the Sequential Organ Failure Assessment (SOFA) and Acute Physiology and Chronic Health Evaluation II (APACHE II) Scores in predicting mortality among intensive care unit (ICU) patients with sepsis in a low-income and middle-income country.DesignA multicentre, cross-sectional study.SettingA total of 15 adult ICUs throughout Vietnam.ParticipantsWe included all patients aged ≥18 years who were admitted to ICUs for sepsis and who were still in ICUs from 00:00 to 23:59 of the specified study days (ie, 9 January, 3 April, 3 July and 9 October of the year 2019).Primary and secondary outcome measuresThe primary outcome was hospital all-cause mortality (hospital mortality). We also defined the secondary outcome as all-cause deaths in the ICU (ICU mortality).ResultsOf 252 patients, 40.1% died in hospitals, and 33.3% died in ICUs. SOFA Score (areas under the receiver operating characteristic curve (AUROC): 0.688 (95% CI 0.618 to 0.758); cut-off value≥7.5; PAUROC<0.001) and APACHE II Score (AUROC: 0.689 (95% CI 0.622 to 0.756); cut-off value ≥20.5; PAUROC<0.001) both had a poor discriminatory ability for predicting hospital mortality. However, the discriminatory ability for predicting ICU mortality of SOFA (AUROC: 0.713 (95% CI 0.643 to 0.783); cut-off value≥9.5; PAUROC<0.001) was fair and was better than that of APACHE II Score (AUROC: 0.672 (95% CI 0.603 to 0.742); cut-off value≥18.5; PAUROC<0.001). A SOFA Score≥8 (adjusted OR (AOR): 2.717; 95% CI 1.371 to 5.382) and an APACHE II Score≥21 (AOR: 2.668; 95% CI 1.338 to 5.321) were independently associated with an increased risk of hospital mortality. Additionally, a SOFA Score≥10 (AOR: 2.194; 95% CI 1.017 to 4.735) was an independent predictor of ICU mortality, in contrast to an APACHE II Score≥19, for which this role did not.ConclusionsIn this study, SOFA and APACHE II Scores were worthwhile in predicting mortality among ICU patients with sepsis. However, due to better discrimination for predicting ICU mortality, the SOFA Score was preferable to the APACHE II Score in predicting mortality.Clinical trials registry – India: CTRI/2019/01/016898.