Details

Autor(en) / Beteiligte

• Ho, Yu-Chieh
• Lai, Yuan-Chun
• Lin, Hsuan-Yu
• Ko, Ming-Hui
• Wang, Sheng-Hung
• Yang, Shan-Jun
• Lin, Po-Ju
• Chou, Tsai-Wei
• Hung, Li-Chung
• Huang, Chia-Chun
• Chang, Tung-Hao
• Lin, Jhen-Bin
• Lin, Jin-Ching

Titel

Low cardiac dose and neutrophil-to-lymphocyte ratio predict overall survival in inoperable esophageal squamous cell cancer patients after chemoradiotherapy

Ist Teil von

• Scientific reports, 2021-03, Vol.11 (1), p.6644-6644, Article 6644

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2021

Quelle

EZB*

Beschreibungen/Notizen

• We aimed to determine the prognostic significance of cardiac dose and hematological immunity parameters in esophageal cancer patients after concurrent chemoradiotherapy (CCRT). During 2010-2015, we identified 101 newly diagnosed esophageal squamous cell cancer patients who had completed definitive CCRT. Patients' clinical, dosimetric, and hematological data, including absolute neutrophil count, absolute lymphocyte count, and neutrophil-to-lymphocyte ratio (NLR), at baseline, during, and post-CCRT were analyzed. Cox proportional hazards were calculated to identify potential risk factors for overall survival (OS). Median OS was 13 months (95% confidence interval [CI]: 10.38-15.63). Univariate analysis revealed that male sex, poor performance status, advanced nodal stage, higher percentage of heart receiving 10 Gy (heart V10), and higher NLR (baseline and follow-up) were significantly associated with worse OS. In multivariate analysis, performance status (ECOG 0 & 1 vs. 2; hazard ratio [HR] 3.12, 95% CI 1.30-7.48), heart V10 (> 84% vs. ≤ 84%; HR 2.24, 95% CI 1.26-3.95), baseline NLR (> 3.56 vs. ≤ 3.56; HR 2.36, 95% CI 1.39-4.00), and follow-up NLR (> 7.4 vs. ≤ 7.4; HR 1.95, 95% CI 1.12-3.41) correlated with worse OS. Volume of low cardiac dose and NLR (baseline and follow-up) were associated with worse patient survival.