Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.2937
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Geobarrettin D, a Rare Herbipoline-Containing 6-Bromoindole Alkaloid from Geodia barretti
- Ist Teil von
- Molecules (Basel, Switzerland), 2023-03, Vol.28 (7), p.2937
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2023
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Geobarrettin D ( ), a new bromoindole alkaloid, was isolated from the marine sponge collected from Icelandic waters. Its structure was elucidated by 1D, and 2D NMR (including H- N HSQC, H- N HMBC spectra), as well as HRESIMS data. Geobarrettin D ( ) is a new 6-bromoindole featuring an unusual purinium herbipoline moiety. Geobarrettin D ( ) decreased secretion of the pro-inflammatory cytokine IL-12p40 by human monocyte derived dendritic cells, without affecting secretion of the anti-inflammatory cytokine IL-10. Thus, compound shows anti-inflammatory activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1420-3049eISSN: 1420-3049DOI: 10.3390/molecules28072937Titel-ID: cdi_doaj_primary_oai_doaj_org_article_c3be15501c57479284de7b26206564c0
- Format
- –
- Schlagworte
- 6-bromoindole, Alkaloids, Alkaloids - pharmacology, Animals, anti-inflammatory activity, Anti-Inflammatory Agents, Communication, Cytokines, Dendritic cells, Geodia - chemistry, Geodia barretti, herbipoline, Humans, Inflammation, Interleukin 10, Interleukin 12, Molecular Structure, Monocytes, Natural products, Oxidation