Details

Autor(en) / Beteiligte

• Chen, Yili
• Zhao, Wen
• Hu, An
• Lin, Shi
• Chen, Ping
• Yang, Bing
• Fan, Zhirong
• Qi, Ji
• Zhang, Wenhui
• Gao, Huanhuan
• Yu, Xiubing
• Chen, Haiyun
• Chen, Luyuan
• Wang, Haizhou

Titel

Type 2 diabetic mellitus related osteoporosis: focusing on ferroptosis

Ist Teil von

• Journal of translational medicine, 2024-04, Vol.22 (1), p.409-409, Article 409

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2024

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• With the aging global population, type 2 diabetes mellitus (T2DM) and osteoporosis(OP) are becoming increasingly prevalent. Diabetic osteoporosis (DOP) is a metabolic bone disorder characterized by abnormal bone tissue structure and reduced bone strength in patients with diabetes. Studies have revealed a close association among diabetes, increased fracture risk, and disturbances in iron metabolism. This review explores the concept of ferroptosis, a non-apoptotic cell death process dependent on intracellular iron, focusing on its role in DOP. Iron-dependent lipid peroxidation, particularly impacting pancreatic β-cells, osteoblasts (OBs) and osteoclasts (OCs), contributes to DOP. The intricate interplay between iron dysregulation, which comprises deficiency and overload, and DOP has been discussed, emphasizing how excessive iron accumulation triggers ferroptosis in DOP. This concise overview highlights the need to understand the complex relationship between T2DM and OP, particularly ferroptosis. This review aimed to elucidate the pathogenesis of ferroptosis in DOP and provide a prospective for future research targeting interventions in the field of ferroptosis.