Details

Autor(en) / Beteiligte

• Zou, Jinping
• Chen, Xinlin
• Liu, Chenxu
• Guo, Mingyue
• Kanwar, Mukesh Kumar
• Qi, Zhenyu
• Yang, Ping
• Wang, Guanghui
• Bao, Yan
• Bassham, Diane C
• Yu, Jingquan
• Zhou, Jie

Titel

Autophagy promotes jasmonate-mediated defense against nematodes

Ist Teil von

• Nature communications, 2023-08, Vol.14 (1), p.4769-4769, Article 4769

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2023

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Autophagy, as an intracellular degradation system, plays a critical role in plant immunity. However, the involvement of autophagy in the plant immune system and its function in plant nematode resistance are largely unknown. Here, we show that root-knot nematode (RKN; Meloidogyne incognita) infection induces autophagy in tomato (Solanum lycopersicum) and different atg mutants exhibit high sensitivity to RKNs. The jasmonate (JA) signaling negative regulators JASMONATE-ASSOCIATED MYC2-LIKE 1 (JAM1), JAM2 and JAM3 interact with ATG8s via an ATG8-interacting motif (AIM), and JAM1 is degraded by autophagy during RKN infection. JAM1 impairs the formation of a transcriptional activation complex between ETHYLENE RESPONSE FACTOR 1 (ERF1) and MEDIATOR 25 (MED25) and interferes with transcriptional regulation of JA-mediated defense-related genes by ERF1. Furthermore, ERF1 acts in a positive feedback loop and regulates autophagy activity by transcriptionally activating ATG expression in response to RKN infection. Therefore, autophagy promotes JA-mediated defense against RKNs via forming a positive feedback circuit in the degradation of JAMs and transcriptional activation by ERF1.