Details

Autor(en) / Beteiligte

• Duncan, Sophie
• Walker, Amy
• Kumar, Shivani
• Dundas, Kylie
• Bell, Katherine
• Wallis, Andrew
• Surjan, Yolanda
• Aly, Farhannah
• Lee, Mark

Titel

Novel methodology to quantify dehydration in head and neck cancer radiotherapy using DIXON MRI

Ist Teil von

• Journal of medical radiation sciences, 2022-12, Vol.69 (4), p.448-455

Ort / Verlag

Richmond: John Wiley & Sons, Inc

Erscheinungsjahr

2022

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Introduction Head and neck cancer (HNC) patients are at risk of weight change, due to inadequate nutrition intake or dehydration, when receiving radiotherapy (RT). This study aimed to develop methodology to measure water content changes on magnetic resonance imaging (MRI) scans of the head and neck region over the course of RT. Methods Retrospective datasets of 54 patients were analysed. Eligible patients had been treated for HNC with cisplatin chemoradiation (CRT) or RT alone and underwent a minimum of 2 MRI scans from weeks 0, 3 and 6 of their treatment. Anatomical regions consisting of ≥90% water, on T2‐weighted DIXON MRI sequences, were contoured. Water volume changes of all patients were evaluated, within an anatomically standardised external volume, by comparing the absolute water fraction volume (cc) (VEx90WF) and relative water fraction volume (%) (RelVEx90WF) at weeks 0 and 6 of RT. Results There was a statistically significant difference between the RelVEx90WF at weeks 0 and 6 (P = 0.005). However, no statistically significant difference was identified between weeks 0 and 6 VEx90WF (P = 0.064). There were no statistically significant differences identified between patients who received CRT versus RT alone. Conclusion This study developed a novel method for measuring changes in water fraction volumes over time, using T2‐weighted DIXON MRIs. The methodology created in this study requires further validation through phantom imaging, with known fat and water values. Head and neck cancer (HNC) patients are at risk of weight change, due to inadequate nutrition intake or dehydration, when receiving radiotherapy (RT). 4This study aimed to develop methodology to measure water content changes on magnetic resonance imaging (MRI) scans of the head and neck region over the course of RT.