Details

Autor(en) / Beteiligte

• Garza Treviño, Elsa N
• Quiroz Reyes, Adriana G
• Rojas Murillo, Juan Antonio
• de la Garza Kalife, David A
• Delgado Gonzalez, Paulina
• Islas, Jose F
• Estrada Rodriguez, Ana Esther
• Gonzalez Villarreal, Carlos A

Titel

Cell Therapy as Target Therapy against Colon Cancer Stem Cells

Ist Teil von

• International journal of molecular sciences, 2023-05, Vol.24 (9), p.8163

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Cancer stem cells (CSCs) are a small subpopulation of cells within tumors with properties, such as self-renewal, differentiation, and tumorigenicity. CSCs have been proposed as a plausible therapeutic target as they are responsible for tumor recurrence, metastasis, and conventional therapy resistance. Selectively targeting CSCs is a promising strategy to eliminate the propagation of tumor cells and impair overall tumor development. Recent research shows that several immune cells play a crucial role in regulating tumor cell proliferation by regulating different CSC maintenance or proliferation pathways. There have been great advances in cellular immunotherapy using T cells, natural killer (NK) cells, macrophages, or stem cells for the selective targeting of tumor cells or CSCs in colorectal cancer (CRC). This review summarizes the CRC molecular profiles that may benefit from said therapy and the main vehicles used in cell therapy against CSCs. We also discuss the challenges, limitations, and advantages of combining conventional and/or current targeted treatments in the late stages of CRC.