Viruses, 2021-09, Vol.13 (9), p.1797
2021
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Details
- Autor(en) / Beteiligte
- Titel
- Recent Advances in Developing Treatments of Kaposi's Sarcoma Herpesvirus-Related Diseases
- Ist Teil von
- Viruses, 2021-09, Vol.13 (9), p.1797
- Ort / Verlag
- Switzerland: MDPI AG
- Erscheinungsjahr
- 2021
- Quelle
- Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals
- Beschreibungen/Notizen
- Kaposi-sarcoma-associated herpesvirus (KSHV) or human herpesvirus 8 (HHV-8) is the causative agent of several malignancies, including Kaposi's sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman's disease (MCD). Active KSHV replication has also been associated with a pathological condition called KSHV inflammatory cytokine syndrome (KICS), and KSHV may play a role in rare cases of post-transplant polyclonal lymphoproliferative disorders. Several commonly used herpesviral DNA polymerase inhibitors are active against KSHV in tissue culture. Unfortunately, they are not always efficacious against KSHV-induced diseases. To improve the outcome for the patients, new therapeutics need to be developed, including treatment strategies that target either viral proteins or cellular pathways involved in tumor growth and/or supporting the viral life cycle. In this review, we summarize the most commonly established treatments against KSHV-related diseases and review recent developments and promising new compounds that are currently under investigation or on the way to clinical use.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1999-4915eISSN: 1999-4915DOI: 10.3390/v13091797Titel-ID: cdi_doaj_primary_oai_doaj_org_article_c25c098e9f5841299fdf65121f0f98e1
- Format
- –
- Schlagworte
- Acquired immune deficiency syndrome, AIDS, Animals, Antigens, Castleman Disease - drug therapy, Cell culture, Clinical Trials as Topic, CRISPR-Cas Systems, Cytokines, Disease, DNA polymerase, DNA-Directed DNA Polymerase, Drugs, Effusion, Exodeoxyribonucleases - antagonists & inhibitors, Gene expression, Gene Expression Regulation, Viral, Genomes, Herpes viruses, Herpesviridae Infections - classification, Herpesviridae Infections - drug therapy, Herpesvirus 8, Human - drug effects, Herpesvirus 8, Human - genetics, HHV-8, HIV, Human immunodeficiency virus, Humans, Immunoproliferative diseases, Inflammation, Kaposi's sarcoma, Kaposis sarcoma, Kinases, KSHV, Life cycles, Lymphocytes, Lymphoma, Lymphoma, Primary Effusion - drug therapy, Mice, multicentric Castleman’s disease, Phosphorylation, Primary effusion lymphoma, Proteins, Review, Sarcoma, Sarcoma, Kaposi - drug therapy, Sarcoma, Kaposi - virology, Tissue culture, Viral Proteins - antagonists & inhibitors, Virus Latency - genetics, Virus Replication - drug effects, Virus Replication - genetics