Details

Autor(en) / Beteiligte

• Pollett, Simon
• Nelson, Martha I
• Kasper, Matthew
• Tinoco, Yeny
• Simons, Mark
• Romero, Candice
• Silva, Marita
• Lin, Xudong
• Halpin, Rebecca A
• Fedorova, Nadia
• Stockwell, Timothy B
• Wentworth, David
• Holmes, Edward C
• Bausch, Daniel G

Titel

Phylogeography of Influenza A(H3N2) Virus in Peru, 2010-2012

Ist Teil von

• Emerging infectious diseases, 2015-08, Vol.21 (8), p.1330-1338

Ort / Verlag

United States: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• It remains unclear whether lineages of influenza A(H3N2) virus can persist in the tropics and seed temperate areas. We used viral gene sequence data sampled from Peru to test this source-sink model for a Latin American country. Viruses were obtained during 2010-2012 from influenza surveillance cohorts in Cusco, Tumbes, Puerto Maldonado, and Lima. Specimens positive for influenza A(H3N2) virus were randomly selected and underwent hemagglutinin sequencing and phylogeographic analyses. Analysis of 389 hemagglutinin sequences from Peru and 2,192 global sequences demonstrated interseasonal extinction of Peruvian lineages. Extensive mixing occurred with global clades, but some spatial structure was observed at all sites; this structure was weakest in Lima and Puerto Maldonado, indicating that these locations may experience greater viral traffic. The broad diversity and co-circulation of many simultaneous lineages of H3N2 virus in Peru suggests that this country should not be overlooked as a potential source for novel pandemic strains.