Details

Autor(en) / Beteiligte

• Lee, Seung Hoon
• Won, Gun-Woo
• Choi, Seung-Hyeon
• Kim, Mi-Yoon
• Oh, Cheong-Hae
• Park, Jong-Tae
• Park, Jong-Il

Titel

Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts

Ist Teil von

• Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113311-113311, Article 113311

Ort / Verlag

Elsevier Masson SAS

Erscheinungsjahr

2022

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Oxidative damage is one of the major causes of human skin aging. Inotodiol is a lanostane triterpenoid that demonstrates antiviral, anticancer, and anti-inflammatory activities. Previous studies have reported that inotodiol also has antiallergic effects. However, whether inotodiol inhibits oxidative stress-induced human skin aging is not known. Stimulation of human dermal fibroblast cells with hydrogen peroxide is related to skin aging. Inotodiol inhibited the expression of mitogen-activated protein kinase (MAPK) and NADPH Oxidase 5 (NOX5). Moreover, inotodiol effectively decreased nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), as well as nitric oxide (NO), reactive oxygen species (ROS), cyclooxygenase-2 (COX-2), and cytokines such as IL-1β, IL-6, and TNF-α. Based on our results, inotodiol protects human dermal fibroblast by preventing MAPK-NOX5 and NF-κB activation and attenuates the expression of aging genes. Inotodiol may therefore be considered a potential candidate for developing natural antiaging products, because it protects the human skin from oxidative stress-induced skin aging by inhibiting the MAPK-NOX5 and NF-κB signaling pathways. [Display omitted] •Inotodiol has an anti-aging effect in human dermal fibroblasts.•Inotodiol inhibits the ROS generation via NOX5.•Inotodiol inhibits the inflammatory cytokines production via NF-κB pathways.