Details

Autor(en) / Beteiligte

• Friesen, Craig A
• Neilan, Nancy
• Daniel, James F
• Radford, Kim
• Schurman, Jennifer V
• Li, Ding-You
• Andre, Linda
• St Peter, Shawn D
• Holcomb, 3rd, George W

Titel

Mast cell activation and clinical outcome in pediatric cholelithiasis and biliary dyskinesia

Ist Teil von

• BMC research notes, 2011-09, Vol.4 (1), p.322-322, Article 322

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2011

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The current study was undertaken to determine the degree of activation of gallbladder mucosal mast cells, whether mast cell (MC) density or activation differ between patients with and without a positive clinical response to cholecystectomy, and whether either density or activation correlate with gallbladder emptying. Fifteen biliary dyskinesia (BD) and 13 symptomatic cholelithiasis (CL) patients undergoing cholecystectomy were prospectively enrolled. Gallbladder wall MC density (by immunohistochemistry) and activation (by electron microscopy) were determined. Clinical response was evaluated 30 days post-cholecystectomy on a 5-point Likert-type scale. A complete or nearly complete clinical response was seen in 100% of CL and in 87% of BD patients. The overall degranulation indices were 49.4 ± 18.7% for CL patients and 44.2 ± 16.8% for BD patients. Neither MC density nor activation correlated with the gallbladder ejection fraction. A complete clinical response was associated with lower epithelial MC density. Cholecystectomy is efficacious in relieving pain in both CL and BD patients. BD and CL are associated not only with increased MC density but a moderate to high degree of MC activation. A possible relationship between MC density and outcome for BD warrants further investigation.