Details

Autor(en) / Beteiligte

• Caussy, Cyrielle
• Tripathi, Anupriya
• Humphrey, Greg
• Bassirian, Shirin
• Singh, Seema
• Faulkner, Claire
• Bettencourt, Ricki
• Rizo, Emily
• Richards, Lisa
• Xu, Zhenjiang Z
• Downes, Michael R
• Evans, Ronald M
• Brenner, David A
• Sirlin, Claude B
• Knight, Rob
• Loomba, Rohit

Titel

A gut microbiome signature for cirrhosis due to nonalcoholic fatty liver disease

Ist Teil von

• Nature communications, 2019-03, Vol.10 (1), p.1406-1406, Article 1406

Ort / Verlag

England: Nature Publishing Group

Erscheinungsjahr

2019

Link zum Volltext

Quelle

The Electronic Journals Library

Beschreibungen/Notizen

• The presence of cirrhosis in nonalcoholic-fatty-liver-disease (NAFLD) is the most important predictor of liver-related mortality. Limited data exist concerning the diagnostic accuracy of gut-microbiome-derived signatures for detecting NAFLD-cirrhosis. Here we report 16S gut-microbiome compositions of 203 uniquely well-characterized participants from a prospective twin and family cohort, including 98 probands encompassing the entire spectrum of NAFLD and 105 of their first-degree relatives, assessed by advanced magnetic-resonance-imaging. We show strong familial correlation of gut-microbiome profiles, driven by shared housing. We report a panel of 30 features, including 27 bacterial features with discriminatory ability to detect NAFLD-cirrhosis using a Random Forest classifier model. In a derivation cohort of probands, the model has a robust diagnostic accuracy (AUROC of 0.92) for detecting NAFLD-cirrhosis, confirmed in a validation cohort of relatives of proband with NAFLD-cirrhosis (AUROC of 0.87). This study provides evidence for a fecal-microbiome-derived signature to detect NAFLD-cirrhosis.