Heliyon, 2023-06, Vol.9 (6), p.e17167-e17167, Article e17167
2023
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Details
- Autor(en) / Beteiligte
- Titel
- Hypoxia inducible factor-1α is an important regulator of macrophage biology
- Ist Teil von
- Heliyon, 2023-06, Vol.9 (6), p.e17167-e17167, Article e17167
- Ort / Verlag
- England: Elsevier Ltd
- Erscheinungsjahr
- 2023
- Quelle
- Alma/SFX Local Collection
- Beschreibungen/Notizen
- Hypoxia-inducible factor-1 (HIF-1), a heterodimeric transcription factor composed of the α and β subunits, regulates cellular adaptive responses to hypoxia. Macrophages, which are derived from monocytes, function as antigen-presenting cells that activate various immune responses. HIF-1α regulates the immune response, viability, migration, phenotypic plasticity, and metabolism of macrophages. Specifically, macrophage-derived HIF-1α can prevent excessive pro-inflammatory responses by attenuating the transcriptional activity of nuclear factor-kappa B in vivo and in vitro. HIF-1α modulates macrophage migration by inducing the release of various chemokines and providing necessary energy. HIF-1α promotes macrophage M1 polarization by targeting glucose metabolism. Additionally, HIF-1α induces the upregulation of glycolysis-related enzymes and intermediates of the tricarboxylic acid cycle and pentose phosphate pathway. HIF-1α promotes macrophage apoptosis, necroptosis and reduces autophagy. The current review highlights the mechanisms associated with the regulation of HIF-1α stabilization in macrophages as well as the role of HIF-1α in modulating the physiological functions of macrophages. [Display omitted]