Journal of otolaryngology-head and neck surgery, 2019-10, Vol.48 (1), p.49-4
2019
Details
- Autor(en) / Beteiligte
- Titel
- The infectious thyroid nodule: a case report of mucormycosis associated with ibrutinib therapy
- Ist Teil von
- Journal of otolaryngology-head and neck surgery, 2019-10, Vol.48 (1), p.49-4
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2019
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Acute invasive fungal infections of the head and neck secondary to tyrosine kinase inhibitors are rare and potentially life-threatening events. We report a case of mucormycosis of the thyroid gland in a patient known for chronic lymphocytic leukemia receiving ibrutinib who presented with a rapidly growing thyroid nodule and dysphonia. An acute invasive fungal infection was identified on a core needle biopsy; mucormycosis was confirmed on culture. The patient was successfully treated with surgical debridement and long-term antifungal therapy. Patients on ibrutinib may be at risk of acute invasive fungal infections of the head and neck.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1916-0216, 1916-0208eISSN: 1916-0216DOI: 10.1186/s40463-019-0376-1Titel-ID: cdi_doaj_primary_oai_doaj_org_article_becdd75854574f2da6a66e32dd3bef9a
- Format
- –
- Schlagworte
- Acute invasive fungal infection, Agammaglobulinaemia Tyrosine Kinase - antagonists & inhibitors, Aged, Anidulafungin, Antifungal agents, Case Report, Case studies, Caspofungin, Chronic lymphocytic leukemia, Cunninghamella - isolation & purification, Diagnosis, Drug therapy, Humans, Ibrutinib, Immunocompromised Host, Infection, Leukemia, Lymphocytic, Chronic, B-Cell - complications, Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy, Lymphocytic leukemia, Male, Micafungin, Mucormycosis, Mucormycosis - etiology, Mycoses, Phenols (Class of compounds), Posaconazole, Pyrazoles - adverse effects, Pyrazoles - therapeutic use, Pyrimidines - adverse effects, Pyrimidines - therapeutic use, Tazobactam, Thyroid cancer, Thyroid diseases, Thyroid gland, Thyroid nodule, Thyroid Nodule - etiology, Thyroid Nodule - microbiology, Thyroid Nodule - pathology, Tyrosine