Details

Autor(en) / Beteiligte

• Lobritz, Michael A
• Ratcliff, Annette N
• Arts, Eric J

Titel

HIV-1 Entry, Inhibitors, and Resistance

Ist Teil von

• Viruses, 2010-05, Vol.2 (5), p.1069-1105

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2010

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Entry inhibitors represent a new class of antiretroviral agents for the treatment of infection with HIV-1. While resistance to other HIV drug classes has been well described, resistance to this new class is still ill defined despite considerable clinical use. Several potential mechanisms have been proposed: tropism switching (utilization of CXCR4 instead of CCR5 for entry), increased affinity for the coreceptor, increased rate of virus entry into host cells, and utilization of inhibitor-bound receptor for entry. In this review we will address the development of attachment, fusion, and coreceptor entry inhibitors and explore recent studies describing potential mechanisms of resistance.