Details

Autor(en) / Beteiligte

• Biran, Roni
• Cohen, Regev
• Finn, Talya
• Brosh-Nissimov, Tal
• Rahav, Galia
• Yahav, Dafna
• Amit, Sharon
• Shachor-Meyouhas, Yael
• Atamna, Alaa
• Bishara, Jihad
• Ashkenazi-Hoffnung, Liat
• Zvi, Haim Ben
• Hershman-Sarafov, Mirit
• Maayan, Shlomo
• Maor, Yasmin
• Schwartz, Orna
• Zimhony, Oren
• Lellouche, Jonathan
• Elbaz, Meital
• Burdelova, Ela
• Mizrahi, Naama
• Novikov, Anna
• Henig, Oryan
• Ben-Ami, Ronen

Titel

Nationwide Outbreak of Candida auris Infections Driven by COVID-19 Hospitalizations, Israel, 2021-2022

Ist Teil von

• Emerging infectious diseases, 2023-07, Vol.29 (7), p.1302-1301

Ort / Verlag

Atlanta: U.S. National Center for Infectious Diseases

Erscheinungsjahr

2023

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• We report an outbreak of Candida auris across multiple healthcare facilities in Israel. For the period of May 2014–May 2022, a total of 209 patients with C. auris infection or colonization were identified. The C. auris incidence rate increased 30-fold in 2021 (p = 0.00015), corresponding in time with surges of COVID-19–related hospitalization. Multilocus sequence typing revealed hospital-level outbreaks with distinct clones. A clade III clone, imported into Israel in 2016, accounted for 48.8% of typed isolates after January 2021 and was more frequently resistant to fluconazole (100% vs. 63%; p = 0.00017) and voriconazole (74% vs. 5.2%; p<0.0001) than were non–clade III isolates. A total of 23% of patients had COVID-19, and 78% received mechanical ventilation. At the hospital level, outbreaks initially involved mechanically ventilated patients in specialized COVID-19 units and then spread sequentially to ventilated non–COVID-19 patients and nonventilated patients.