Trials, 2018-09, Vol.19 (1), p.497-497, Article 497
2018
Details
- Autor(en) / Beteiligte
- Titel
- Caveat emptor: the combined effects of multiplicity and selective reporting
- Ist Teil von
- Trials, 2018-09, Vol.19 (1), p.497-497, Article 497
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2018
- Link zum Volltext
- Quelle
- SpringerLink Journals
- Beschreibungen/Notizen
- Clinical trials and systematic reviews of clinical trials inform healthcare decisions. There is growing concern, however, about results from clinical trials that cannot be reproduced. Reasons for nonreproducibility include that outcomes are defined in multiple ways, results can be obtained using multiple methods of analysis, and trial findings are reported in multiple sources ("multiplicity"). Multiplicity combined with selective reporting can influence dissemination of trial findings and decision-making. In particular, users of evidence might be misled by exposure to selected sources and overly optimistic representations of intervention effects. In this commentary, drawing from our experience in the Multiple Data Sources in Systematic Reviews (MUDS) study and evidence from previous research, we offer practical recommendations to enhance the reproducibility of clinical trials and systematic reviews.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1745-6215eISSN: 1745-6215DOI: 10.1186/s13063-018-2888-9Titel-ID: cdi_doaj_primary_oai_doaj_org_article_bcc2b73ae775426eac952fbc13e90fd8
- Format
- –
- Schlagworte
- Clinical Decision-Making, Clinical trials, Data Accuracy, Evidence-based medicine, Evidence-Based Medicine - methods, Humans, Management, Medical research, Methods, Multiplicity, Randomized Controlled Trials as Topic - methods, Reproducibility, Reproducibility of Results, Research Design, Selective reporting, Statistics (Mathematics), Systematic Reviews as Topic