Details

Autor(en) / Beteiligte

• Dabrowski, Alexander N
• Conrad, Claudia
• Behrendt, Ulrike
• Shrivastav, Anshu
• Baal, Nelli
• Wienhold, Sandra M
• Hackstein, Holger
• N'Guessan, Philippe D
• Aly, Sahar
• Reppe, Katrin
• Suttorp, Norbert
• Zahlten, Janine

Titel

Peptidoglycan Recognition Protein 2 Regulates Neutrophil Recruitment Into the Lungs After Streptococcus pneumoniae Infection

Ist Teil von

• Frontiers in microbiology, 2019-02, Vol.10, p.199-199

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Peptidoglycan (PGN) recognition proteins (PGLYRPs) are a highly conserved group of host defense proteins in insects and mammals that sense bacterial cell wall PGN and act bactericidally or cleave PGN by amidase function. ( ) is one of the top five killers worldwide and causes, e.g., pneumonia, endocarditis, meningitis and sepsis. accounts for approximately 1.5-2 million deaths every year. The risk of antibiotic resistance and a general poor prognosis in young children and elderly people have led to the need for new treatment approaches. To the best of our knowledge, there is no report on the relevance of PGLYRP2 in lung infections. Therefore, we infected mice deficient for PGLYRP2 transnasally with and examined the innate immune response in comparison to WT animals. As expected, PGLYRP2-KO animals had to be sacrificed earlier than their WT counterparts, and this was due to higher bacteremia. The higher bacterial load in the PGLYRP2-KO mice was accomplished with lower amounts of proinflammatory cytokines in the lungs. This led to an abolished recruitment of neutrophils into the lungs, the spread of bacteria and the subsequent aggravated course of the disease and early mortality of the PGLYRP2-KO mice. These data suggest a substantial role of PGLYRP2 in the early defense against infection, and PGLYRP2 might also affect other infections in the lungs.