Details

Autor(en) / Beteiligte

• Than, Nandor Gabor
• Romero, Roberto
• Tarca, Adi Laurentiu
• Kekesi, Katalin Adrienna
• Xu, Yi
• Xu, Zhonghui
• Juhasz, Kata
• Bhatti, Gaurav
• Leavitt, Ron Joshua
• Gelencser, Zsolt
• Palhalmi, Janos
• Chung, Tzu Hung
• Gyorffy, Balazs Andras
• Orosz, Laszlo
• Demeter, Amanda
• Szecsi, Anett
• Hunyadi-Gulyas, Eva
• Darula, Zsuzsanna
• Simor, Attila
• Eder, Katalin
• Szabo, Szilvia
• Topping, Vanessa
• El-Azzamy, Haidy
• LaJeunesse, Christopher
• Balogh, Andrea
• Szalai, Gabor
• Land, Susan
• Torok, Olga
• Dong, Zhong
• Kovalszky, Ilona
• Falus, Andras
• Meiri, Hamutal
• Draghici, Sorin
• Hassan, Sonia S
• Chaiworapongsa, Tinnakorn
• Krispin, Manuel
• Knöfler, Martin
• Erez, Offer
• Burton, Graham J
• Kim, Chong Jai
• Juhasz, Gabor
• Papp, Zoltan

Titel

Integrated Systems Biology Approach Identifies Novel Maternal and Placental Pathways of Preeclampsia

Ist Teil von

• Frontiers in immunology, 2018-08, Vol.9, p.1661-1661

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2018

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Preeclampsia is a disease of the mother, fetus, and placenta, and the gaps in our understanding of the complex interactions among their respective disease pathways preclude successful treatment and prevention. The placenta has a key role in the pathogenesis of the terminal pathway characterized by exaggerated maternal systemic inflammation, generalized endothelial damage, hypertension, and proteinuria. This of preeclampsia may be triggered by distinct underlying mechanisms that occur at early stages of pregnancy and induce different phenotypes. To gain insights into these molecular pathways, we employed a systems biology approach and integrated different "omics," clinical, placental, and functional data from patients with distinct phenotypes of preeclampsia. First trimester maternal blood proteomics uncovered an altered abundance of proteins of the renin-angiotensin and immune systems, complement, and coagulation cascades in patients with term or preterm preeclampsia. Moreover, first trimester maternal blood from preterm preeclamptic patients dysregulated trophoblastic gene expression. Placental transcriptomics of women with preterm preeclampsia identified distinct gene modules associated with maternal or fetal disease. Placental "virtual" liquid biopsy showed that the dysregulation of these disease gene modules originates during the first trimester. experiments on hub transcription factors of these gene modules demonstrated that DNA hypermethylation in the regulatory region of leads to gene down-regulation and impaired trophoblast invasion, while and up-regulation sensitizes the trophoblast to ischemia, hallmarks of preterm preeclampsia. In summary, our data suggest that there are distinct maternal and placental disease pathways, and their interaction influences the clinical presentation of preeclampsia. The activation of maternal disease pathways can be detected in all phenotypes of preeclampsia earlier and upstream of placental dysfunction, not only downstream as described before, and distinct placental disease pathways are superimposed on these maternal pathways. This is a paradigm shift, which, in agreement with epidemiological studies, warrants for the central pathologic role of preexisting maternal diseases or perturbed maternal-fetal-placental immune interactions in preeclampsia. The description of these novel pathways in the "molecular phase" of preeclampsia and the identification of their hub molecules may enable timely molecular characterization of patients with distinct preeclampsia phenotypes.