Details

Autor(en) / Beteiligte

• Hassan, Amani
• Bagu, Edward T
• Levesque, Mathieu
• Patten, Shunmoogum A
• Benhadjeba, Samira
• Edjekouane, Lydia
• Villemure, Isabelle
• Tremblay, André
• Moldovan, Florina

Titel

The 17β-Estradiol induced upregulation of the Adhesion G-protein coupled receptor (ADGRG7) is modulated by ESRα and SP1 complex

Ist Teil von

• Biology open, 2019-01, Vol.8 (1)

Ort / Verlag

England: The Company of Biologists Ltd

Erscheinungsjahr

2019

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• The physiological role and the regulation of ADGRG7 are not yet elucidated. The functional involvement of this receptor was linked with different physiological process such as reduced body weight, gastrointestinal function and recently, a gene variant in ADGRG7 was observed in patients with idiopathic scoliosis. The physiological role and the regulation of Adhesion G protein coupled receptor7 (ADGRG7) are not yet elucidated. The functional involvement of this receptor was linked with different physiological process such as reduced body weight, gastrointestinal function and recently, a gene variant in ADGRG7 was observed in patients with adolescent idiopathic scoliosis. Here, we identify the as an estrogen-responsive gene under the regulation of estrogen receptor ERα in scoliotic osteoblasts and other cells lines. We found that expression was upregulated in response to estrogen (E2) in adolescent idiopathic scoliosis (AIS) cells. promoter studies indicate the presence of an ERα response half site in close vicinity of an SP1 binding site. Mutation of the SP1 site completely abrogated the response to E2, indicating its essential requirement. ChIP confirmed the binding of SP1 and ERα to the promoter. Our results identify the gene as an estrogen-responsive gene under the control of ERα and SP1 tethered actions, suggesting a possible role of estrogens in the regulation of .