Details

Autor(en) / Beteiligte

• Shapiro, Daniel D
• Virumbrales-Muñoz, Maria
• Beebe, David J
• Abel, E Jason

Titel

Models of Renal Cell Carcinoma Used to Investigate Molecular Mechanisms and Develop New Therapeutics

Ist Teil von

• Frontiers in oncology, 2022-04, Vol.12, p.871252-871252

Ort / Verlag

Switzerland: Frontiers Media S.A

Erscheinungsjahr

2022

Link zum Volltext

Quelle

EZB Free E-Journals

Beschreibungen/Notizen

• Modeling renal cell carcinoma is critical to investigating tumor biology and therapeutic mechanisms. Multiple systems have been developed to represent critical components of the tumor and its surrounding microenvironment. Prominent models include traditional cell cultures, 3D organoid models, and microphysiological devices. models consist of murine patient derived xenografts or genetically engineered mice. Each system has unique advantages as well as limitations and researchers must thoroughly understand each model to properly investigate research questions. This review addresses common model systems for renal cell carcinoma and critically evaluates their performance and ability to measure tumor characteristics.