PLoS genetics, 2014-12, Vol.10 (12), p.e1004829-e1004829
2014
Details
- Autor(en) / Beteiligte
- Titel
- Germline signals deploy NHR-49 to modulate fatty-acid β-oxidation and desaturation in somatic tissues of C. elegans
- Ist Teil von
- PLoS genetics, 2014-12, Vol.10 (12), p.e1004829-e1004829
- Ort / Verlag
- United States: Public Library of Science
- Erscheinungsjahr
- 2014
- Link zum Volltext
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- In C. elegans, removal of the germline extends lifespan significantly. We demonstrate that the nuclear hormone receptor, NHR-49, enables the response to this physiological change by increasing the expression of genes involved in mitochondrial β-oxidation and fatty-acid desaturation. The coordinated augmentation of these processes is critical for germline-less animals to maintain their lipid stores and to sustain de novo fat synthesis during adulthood. Following germline ablation, NHR-49 is up-regulated in somatic cells by the conserved longevity determinants DAF-16/FOXO and TCER-1/TCERG1. Accordingly, NHR-49 overexpression in fertile animals extends their lifespan modestly. In fertile adults, nhr-49 expression is DAF-16/FOXO and TCER-1/TCERG1 independent although its depletion causes age-related lipid abnormalities. Our data provide molecular insights into how reproductive stimuli are integrated into global metabolic changes to alter the lifespan of the animal. They suggest that NHR-49 may facilitate the adaptation to loss of reproductive potential through synchronized enhancement of fatty-acid oxidation and desaturation, thus breaking down some fats ordained for reproduction and orchestrating a lipid profile conducive for somatic maintenance and longevity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1553-7404, 1553-7390eISSN: 1553-7404DOI: 10.1371/journal.pgen.1004829Titel-ID: cdi_doaj_primary_oai_doaj_org_article_b817cd8b991d4476a246d13b6a7675ea
- Format
- –
- Schlagworte
- Animals, Animals, Genetically Modified, Biology and Life Sciences, Caenorhabditis elegans, Caenorhabditis elegans - genetics, Caenorhabditis elegans - metabolism, Caenorhabditis elegans Proteins - genetics, Caenorhabditis elegans Proteins - metabolism, Caenorhabditis elegans Proteins - physiology, Cellular signal transduction, Fatty acids, Fatty Acids - metabolism, Female, Forkhead Transcription Factors - metabolism, Germ Cells - metabolism, Health aspects, Lipid Metabolism - genetics, Longevity - genetics, Microbiological research, Oxidation-Reduction, Oxidation-reduction reaction, Peptide Elongation Factors - metabolism, Receptors, Cytoplasmic and Nuclear - genetics, Receptors, Cytoplasmic and Nuclear - metabolism, Receptors, Cytoplasmic and Nuclear - physiology, Reproduction - genetics, Signal Transduction - genetics