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Details

Autor(en) / Beteiligte
Titel
Proteome differences associated with fat accumulation in bovine subcutaneous adipose tissues
Ist Teil von
  • Proteome science, 2010-03, Vol.8 (1), p.14-14, Article 14
Ort / Verlag
England: BioMed Central Ltd
Erscheinungsjahr
2010
Link zum Volltext
Quelle
EZB Electronic Journals Library
Beschreibungen/Notizen
  • The fat components of red meat products have been of interest to researchers due to the health aspects of excess fat consumption by humans. We hypothesized that differences in protein expression have an impact on adipose tissue formation during beef cattle development and growth. Therefore, in this study we evaluated the differences in the discernable proteome of subcutaneous adipose tissues of 35 beef crossbred steers [Charolais x Red Angus (CHAR) (n = 13) and Hereford x Angus (HEAN) (n = 22)] with different back fat (BF) thicknesses. The goal was to identify specific protein markers that could be associated with adipose tissue formation in beef cows. Approximately 541-580 protein spots were detected and compared in each crossbred group, and 33 and 36 protein spots showed expression differences between tissues with high and low BF thicknesses from HEAN and CHAR crossbed, respectively. The annexin 1 protein was highly expressed in both crossbred steers that had a higher BF thickness (p < 0.05) and this was further validated by a western blot analysis. In 13 tissues of CHAR animals and 22 tissues of HEAN animals, the relative expression of annexin 1 was significantly different (p < 0.05) between tissues with high and low BF thicknesses. The increased expression of annexin 1 protein has been found to be associated with higher BF thickness in both crossbred steers. This result lays the foundation for future studies to develop the protein marker for assessing animals with different BF thickness.
Sprache
Englisch
Identifikatoren
ISSN: 1477-5956
eISSN: 1477-5956
DOI: 10.1186/1477-5956-8-14
Titel-ID: cdi_doaj_primary_oai_doaj_org_article_b7821771aa834458a7f5c266b4e1bee4

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