Details

Autor(en) / Beteiligte

• Boska, Michael D
• Hasan, Khader M
• Kibuule, Danette
• Banerjee, Rebecca
• McIntyre, Erin
• Nelson, Jay A
• Hahn, Theresa
• Gendelman, Howard E
• Mosley, R. Lee

Titel

Quantitative diffusion tensor imaging detects dopaminergic neuronal degeneration in a murine model of Parkinson’s disease

Ist Teil von

• Neurobiology of disease, 2007-06, Vol.26 (3), p.590-596

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2007

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Abstract Early diagnosis of Parkinson’s disease (PD) is required to improve therapeutic responses. Indeed, a clinical diagnosis of resting tremor, rigidity, movement and postural deficiencies usually reflect > 50% loss of the nigrostriatal system in disease. In a step to address this, quantitative diffusion tensor magnetic resonance imaging (DTI) was used to assess nigrostriatal degeneration in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) intoxication model of dopaminergic nigral degeneration. We now demonstrate increased average diffusion ( p < 0.005) and decreased fractional anisotropy ( p < 0.03) in the substantia nigra (SN) of 5- to 7-day MPTP-treated animals when compared to saline controls. Transverse diffusivity demonstrated the most significant differences ( p ≤ 0.002) and correlated with the numbers of SN dopaminergic neurons ( r = − 0.75, p = 0.012). No differences were found in the striatum, corpus callosum, cerebral cortex, or ventricles. These results demonstrate that DTI may be used as a surrogate biomarker of nigral dopaminergic neuronal degeneration.