Details

Autor(en) / Beteiligte

• Coppola, Serena
• Avagliano, Carmen
• Sacchi, Antonia
• Laneri, Sonia
• Calignano, Antonio
• Voto, Luana
• Luzzetti, Anna
• Berni Canani, Roberto

Titel

Potential Clinical Applications of the Postbiotic Butyrate in Human Skin Diseases

Ist Teil von

• Molecules (Basel, Switzerland), 2022-03, Vol.27 (6), p.1849

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2022

Quelle

MEDLINE

Beschreibungen/Notizen

• Human skin is the largest organ and the most external interface between the environment and the body. Vast communities of viruses, bacteria, archaea, fungi, and mites, collectively named the skin microbiome (SM), cover the skin surface and connected structures. Skin-resident microorganisms contribute to the establishment of cutaneous homeostasis and can modulate host inflammatory responses. Imbalances in the SM structure and function (dysbiosis) are associated with several skin conditions. Therefore, novel target for the skincare field could be represented by strategies, which restore or preserve the SM natural/individual balance. Several of the beneficial effects exerted by the SM are aroused by the microbial metabolite butyrate. Since butyrate exerts a pivotal role in preserving skin health, it could be used as a postbiotic strategy for preventing or treating skin diseases. Herein, we describe and share perspectives of the potential clinical applications of therapeutic strategies using the postbiotic butyrate against human skin diseases.