Details

Autor(en) / Beteiligte

• Jonas, Marta Izabela
• Kurylowicz, Alina
• Bartoszewicz, Zbigniew
• Lisik, Wojciech
• Jonas, Maurycy
• Domienik-Karlowicz, Justyna
• Puzianowska-Kuznicka, Monika

Titel

Adiponectin/resistin interplay in serum and in adipose tissue of obese and normal-weight individuals

Ist Teil von

• Diabetology and metabolic syndrome, 2017-12, Vol.9 (1), p.95-95, Article 95

Ort / Verlag

England: BioMed Central Ltd

Erscheinungsjahr

2017

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The interplay between adiponectin and resistin, the two adipokines of opposite effects, may determine the metabolic profile of obese individuals and development of obesity-related complications. The current study was conducted to assess how adiponectin/resistin interplay in sera and adipose tissues may influence the metabolic profile of obese and normal-weight subjects. Concentrations of adiponectin and resistin were measured on protein level by immunoassay in visceral and subcutaneous adipose tissues from 50 obese (body mass index > 40 kg/m ) and 28 normal-weight (body mass index 20-24.9 kg/m ) individuals. Simultaneously expression of and (encoding adiponectin and resistin, respectively) was assessed on mRNA level by real-time PCR. mRNA (P = 0.0001) and adiponectin protein (P = 0.0013) levels were lower, while mRNA (P = 0.0338) and resistin (P < 0.0001)-higher in subcutaneous adipose tissues of obese subjects. and mRNA levels did not correlate with protein concentrations in the investigated adipose tissues. In obesity adiponectin serum concentrations correlated positively with mRNA in subcutaneous adipose tissue (P = 0.005) and negatively with protein levels in visceral adipose tissue (P = 0.001). Obesity was associated with higher adiponectin-resistin index value in sera (P < 0.0001) and decreased in subcutaneous adipose tissue (P < 0.001), but only adiponectin-resistin index measured in sera was significantly higher in obese with the metabolic syndrome (P = 0.04). Obesity affects synthesis of adiponectin and resistin mainly in subcutaneous adipose tissue. The adiponectin-resistin index assessed in the adipose tissues has a different prognostic value compared to the adiponectin-resistin index in serum and does not reflect a metabolic risk in obese individuals.