Details

Autor(en) / Beteiligte

• Oh, Min-Hee
• Collins, Samuel L.
• Sun, Im-Hong
• Tam, Ada J.
• Patel, Chirag H.
• Arwood, Matthew L.
• Chan-Li, Yee
• Powell, Jonathan D.
• Horton, Maureen R.

Titel

mTORC2 Signaling Selectively Regulates the Generation and Function of Tissue-Resident Peritoneal Macrophages

Ist Teil von

• Cell reports (Cambridge), 2017-09, Vol.20 (10), p.2439-2454

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2017

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• Tissue-resident macrophages play critical roles in sentinel and homeostatic functions as well as in promoting inflammation and immunity. It has become clear that the generation of these cells is highly dependent upon tissue-specific cues derived from the microenvironment that, in turn, regulate unique differentiation programs. Recently, a role for GATA6 has emerged in the differentiation programming of resident peritoneal macrophages. We identify a critical role for mTOR in integrating cues from the tissue microenvironment in regulating differentiation and metabolic reprogramming. Specifically, inhibition of mTORC2 leads to enhanced GATA6 expression in a FOXO1 dependent fashion. Functionally, inhibition of mTORC2 promotes peritoneal resident macrophage generation in the resolution phase during zymosan-induced peritonitis. Also, mTORC2-deficient peritoneal resident macrophages displayed increased functionality and metabolic reprogramming. Notably, mTORC2 activation distinguishes tissue-resident macrophage proliferation and differentiation from that of M2 macrophages. Overall, our data implicate a selective role for mTORC2 in the differentiation of tissue-resident macrophages. [Display omitted] •mTORC2 activity is lower in tissue-resident peritoneal macrophages•mTORC2 inhibits the generation and activity of tissue-resident peritoneal macrophages•mTORC2 signaling negatively regulates GATA6 expression by controlling FOXO1 activity•mTORC2 is important for the metabolic reprogramming of tissue-resident macrophages Oh et al. identify the mTORC2-FOXO1 axis as playing a critical role in integrating cues from the microenvironment to regulate metabolic reprogramming, differentiation, and function of peritoneal tissue-resident macrophages.