Details

Autor(en) / Beteiligte

• Lin Zhou PhD
• Jing Wang MD
• Shao-cheng Lyu PhD
• Li-chao Pan PhD
• Xian-jie Shi PhD
• Guo-sheng Du PhD
• Qiang He PhD

Titel

PD-L1NEUT, Foxp3Treg, and NLR as New Prognostic Marker with Low Survival Benefits Value in Hepatocellular Carcinoma

Ist Teil von

• Technology in cancer research & treatment, 2021-09, Vol.20

Ort / Verlag

SAGE Publishing

Erscheinungsjahr

2021

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Background: This presented study was aimed to evaluate the diagnostic and prognostic value of PD-L1 + Neutrophils (PD-L1 + NEUT) and neutrophil to lymphocyte ratio (NLR) based on our previous experience of Foxp3 + Treg in transplantation. Methods: the NLR cutoff value of 1.79 was used to include 136 cases from the 204 patients with hepatocellular carcinoma (HCC) confirmed by clinical pathology, which were divided into highly-moderately and poorly differentiated HCC groups. The expressions of PD-L1 + NEUT and Foxp3 + Treg in peripheral blood and cancer tissue were detected with flow cytometry, meanwhile, PD-L1 and Foxp3 expressed in carcinoma and para-carcinoma tissues were marked by immunohistochemistry. Survival rates, including overall survival and disease-free survival, were calculated by the Kaplan–Meier curve and evaluated with the log-rank test. Finally, Cox risk regression model was used to analyze the independent risk factors for prognostic survival. Results: The level of PD-L1 + NEUT, Foxp3 + Treg, and NLR in peripheral blood of patients with poorly differentiated HCC were significantly increased (all P  < .001). Both PD-L1 + NEUT and NLR were positively correlated with Foxp3 + Treg ( r  = 0.479, P  = .0017; r  = 0.58, P  < .0001). The level of PD-L1 + NEUT and Foxp3 + Treg as well as PD-L1 and Foxp3 in cancer tissue and patients with poorly differentiated HCC were obviously increased (all P  < .01), respectively. Cox regression analysis indicated that PD-L1 + NEUT, NLR, and Foxp3 + Treg were independent risk factors for the prognosis ( P  = .000, .000, .006) with a RR and 95%CI of 2.704-(2.155-3.393), 3.139-(2.361-4.173), 1.409-(1.105-1.798), respectively. Conclusion: PD-L1 + NEUT, NLR, and Foxp3 + Treg are independent risk factors for prognosis which maybe new marker of lower survival benefits.