Details

Autor(en) / Beteiligte

• Cerrato-Izaguirre, Dennis
• Chirino, Yolanda I.
• Prada, Diddier
• Quezada-Maldonado, Ericka Marel
• Herrera, Luis A
• Hernández-Guerrero, Angélica
• Alonso-Larraga, Juan Octavio
• Herrera-Goepfert, Roberto
• Oñate-Ocaña, Luis F.
• Cantú-de-León, David
• Meneses-García, Abelardo
• Basurto-Lozada, Patricia
• Robles-Espinoza, Carla Daniela
• Camacho, Javier
• García-Cuellar, Claudia M.
• Sánchez-Pérez, Yesennia

Titel

Somatic Mutational Landscape in Mexican Patients: CDH1 Mutations and chr20q13.33 Amplifications Are Associated with Diffuse-Type Gastric Adenocarcinoma

Ist Teil von

• International journal of molecular sciences, 2022-10, Vol.23 (19), p.11116

Ort / Verlag

Basel: MDPI AG

Erscheinungsjahr

2022

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• The Hispanic population, compared with other ethnic groups, presents a more aggressive gastric cancer phenotype with higher frequency of diffuse-type gastric adenocarcinoma (GA); this could be related to the mutational landscape of GA in these patients. Using whole-exome sequencing, we sought to present the mutational landscape of GA from 50 Mexican patients who were treated at The Instituto Nacional de Cancerología from 2019 to 2020. We performed a comprehensive statistical analysis to explore the relationship of the genomic variants and clinical data such as tumor histology and presence of signet-ring cell, H. pylori, and EBV. We describe a potentially different mutational landscape between diffuse and intestinal GA in Mexican patients. Patients with intestinal-type GA tended to present a higher frequency of NOTCH1 mutations, copy number gains in cytobands 13.14, 10q23.33, and 12q25.1, and copy number losses in cytobands 7p12, 14q24.2, and 11q13.1; whereas patients with diffuse-type GA tended to present a high frequency of CDH1 mutations and CNV gains in cytobands 20q13.33 and 22q11.21. This is the first description of a mutational landscape of GA in Mexican patients to better understand tumorigenesis in Hispanic patients and lay the groundwork for discovering potential biomarkers and therapeutic targets.