Details

Autor(en) / Beteiligte

• Yalamanchi, Ashna
• Gill, Jaya Mini
• Truong, Judy
• Nguyen, Minhdan
• Carrillo, Jose
• Wagle, Naveed
• Sharma, Akanksha
• Kesari, Santosh

Titel

Molecularly targeted treatment of recurrent anaplastic astrocytoma – a case report

Ist Teil von

• Annals of clinical and translational neurology, 2021-09, Vol.8 (9), p.1913-1916

Ort / Verlag

United States: John Wiley & Sons, Inc

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Wiley Online Library Journals Frontfile Complete

Beschreibungen/Notizen

• High‐grade astrocytomas are malignant and aggressive, with limited treatment options. Treatment is geared not only toward increasing patient’s overall survival but also in delaying or preventing neurological disability, a cause of significant morbidity. Increasingly, targeted and customized treatment approaches, especially for recurrent disease, are being explored. Here we present a successful outcome in a young patient with rapidly progressive disease who responded to targeted treatment based on genetic sequencing and circulating tumor DNA markers, given the inaccessibility of the tissue to biopsy. Molecular testing on tissue, serum or CSF may be helpful in identifying unique targets in these complex patients.