Details

Autor(en) / Beteiligte

• Sadowska, Anna
• Zapora, Ewa
• Sawicka, Diana
• Niemirowicz-Laskowska, Katarzyna
• Surażyński, Arkadiusz
• Sułkowska-Ziaja, Katarzyna
• Kała, Katarzyna
• Stocki, Marcin
• Wołkowycki, Marek
• Bakier, Sławomir
• Pawlik, Anna
• Jaszek, Magdalena
• Muszyńska, Bożena
• Car, Halina

Titel

Heterobasidion annosum Induces Apoptosis in DLD-1 Cells and Decreases Colon Cancer Growth in In Vivo Model

Ist Teil von

• International journal of molecular sciences, 2020-05, Vol.21 (10), p.3447

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2020

Quelle

MEDLINE

Beschreibungen/Notizen

• Application of substances from medicinal mushrooms is one of the interesting approaches to improve cancer therapy. In this study, we commenced a new attempt in the field of (Fr.) Bref. sensu lato to further extend our knowledge on this basidiomycete fungus. For this purpose, analysis of the active substances of methanolic extract and also its influence on colorectal cancer in terms of in vitro and in vivo experiments were performed. In vivo studies on mice were conducted to verify its acute toxicity and to further affirm its anticancer potential. Results indicated that all the most common substances of best known medicinal mushrooms that are also responsible for their biological activity are present in tested extracts. In vitro tests showed a high hemocompatibility and a significant decrease in viability and proliferation of DLD-1 cells in a concentration-dependent manner of extract. The studies performed on xenograft model of mice showed lower tendency of tumor growth in the group of mice receiving extract as well as mild or moderate toxicity. Obtained results suggest beneficial potential of against colon cancer as cytotoxic agent or as adjuvant anticancer therapy.