Details

Autor(en) / Beteiligte

• do Espírito Santo Júnior, José
• Gabrielle Ramos de Mesquita, Tirza
• Diego Oliveira da Silva, Luan
• Jules de Araújo, Felipe
• Lacerda de Souza, Josué
• Carneiro de Lacerda, Thaís
• Santos da Silva, Lener
• Marcello da Silveira Júnior, Cláudio
• Layane Guimarães Duarte Queiroz, Krys
• Dos Santos, Diogo Matos
• Chagas da Silva, Cilana
• David Graterol Sequera, Héctor
• Tamayo Hermida, Melissa
• Lúcia Gomes de Souza, Mara
• Vinitius de Farias Guerra, Marcus
• Ramasawmy, Rajendranath

Titel

TREM1 rs2234237 (Thr25Ser) Polymorphism in Patients with Cutaneous Leishmaniasis Caused by Leishmania guyanensis : A Case-Control Study in the State of Amazonas, Brazil

Ist Teil von

• Pathogens (Basel), 2021-04, Vol.10 (4), p.498

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Leishmaniasis is an infectious disease caused by parasites. A Th1 immune response is necessary in the acute phase to control the pathogen. The triggering receptor expressed on myeloid cells (TREM)-1 is a potent amplifier of inflammation. Our aim is to identify whether the variant rs2234237 A/T (Thr25Ser) is associated with the disease development of cutaneous leishmaniasis (CL) in -infected individuals. The effects of the rs2234237 genotypes on plasma cytokines IL-1β, IL-6, IL-8, IL-10, MCP-1 and TNF-α are also investigated. 838 patients with CL and 818 healthy controls (HCs) living in the same endemic areas were genotyped by Polymerase Chain Reaction-Restriction Fragment Length Polymorphism. Plasma cytokines were assayed in 400 patients with CL and 400 HCs using the BioPlex assay. The genotypes' and alleles' frequencies were similar in both patients with CL (AA = 618, 74%; AT = 202, 24%; TT = 18, 2%) and in HCs (AA = 580, 71%; AT = 220, 27%; TT = 18, 2%). Rs2234237 showed a modest effect on plasma IL-10 that disappeared when correction of the -value was applied. Plasma IL-10 by rs2234237 genotypes were (mean ± SEM; AA = 2.91 pg/mL ± 0.14; AT = 2.35 pg/mL ± 0.12; TT = 3.14 pg/mL ± 0.56; = 0.05). The rs2234237 (Thr25Ser) seems to have no influence on the susceptibility or resistance to infections.