Details

Autor(en) / Beteiligte

• Bestetti, Stefano
• Galli, Mauro
• Sorrentino, Ilaria
• Pinton, Paolo
• Rimessi, Alessandro
• Sitia, Roberto
• Medraño-Fernandez, Iria

Titel

Human aquaporin-11 guarantees efficient transport of H2O2 across the endoplasmic reticulum membrane

Ist Teil von

• Redox biology, 2020-01, Vol.28, p.101326, Article 101326

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2020

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Hydrogen peroxide (H2O2) is an essential second intracellular messenger. To reach its targets in the cytosol, H2O2 must cross a membrane, a feat that requires aquaporins (AQP) endowed with ‘peroxiporin’ activity (AQP3, AQP8, AQP9). Here, we exploit different organelle-targeted H2O2-sensitive probes to show that also AQP11 efficiently conduits H2O2. Unlike other peroxiporins, AQP11 is localized in the endoplasmic reticulum (ER), accumulating partly in mitochondrial-associated ER membranes (MAM). Its downregulation severely perturbs the flux of H2O2 through the ER, but not through the mitochondrial or plasma membranes. These properties make AQP11 a potential regulator of ER redox homeostasis and signaling. [Display omitted] •AQP11 is an endoplasmic reticulum (ER)-resident peroxiporin.•AQP11 allows H2O2 fluxes across the ER membrane.•Its levels impact ER redox homeostasis.