Details

Autor(en) / Beteiligte

• Leong, Darryl P
• Loeb, Mark
• Mony, Prem K
• Rangarajan, Sumathy
• Mushtaha, Maha
• Miller, Matthew S
• Dias, Mary
• Yegorov, Sergey
• V, Mamatha
• Telci Caklili, Ozge
• Temizhan, Ahmet
• Szuba, Andrzej
• Abat, Marc Evans M
• Mat-Nasir, Nafiza
• Diaz, Maria Luz
• Khansaheb, Hamda
• Lopez-Jaramillo, Patricio
• Duong, MyLinh
• Teo, Koon K
• Poirier, Paul
• Oliveira, Gustavo
• Avezum, Álvaro
• Yusuf, Salim
• Laeyendecker, Oliver

Titel

Risk factors for recognized and unrecognized SARS-CoV-2 infection: a seroepidemiologic analysis of the Prospective Urban Rural Epidemiology (PURE) study

Ist Teil von

• Microbiology spectrum, 2024-02, Vol.12 (2), p.e0149223-e0149223

Ort / Verlag

United States: American Society for Microbiology

Erscheinungsjahr

2024

Quelle

MEDLINE

Beschreibungen/Notizen

• There are limited data on individual risk factors for SARS-CoV-2 infection (including unrecognized infection). In this seroepidemiologic substudy of an ongoing prospective cohort study of community-dwelling adults, participants were thoroughly characterized pre-pandemic. The SARS-CoV-2 infection was ascertained by serology. Among 8,719 participants from 11 high-, middle-, and low-income countries, 3,009 (35%) were seropositive for SARS-CoV-2. Characteristics independently associated with seropositivity were younger age (odds ratio, OR; 95% confidence interval, CI, per five-year increase: 0.95; 0.91-0.98) and body mass index >25 kg/m (OR, 95% CI: 1.16, 1.01-1.34). Smoking (as compared with never smoking, OR, 95% CI: 0.83, 0.70-0.97) and COVID-19 vaccination (OR, 95% CI: 0.70, 0.60-0.82) were associated with a reduced risk of seropositivity. Among seropositive participants, 83% were unaware of having been infected with SARS-CoV-2. Seropositivity and a lack of awareness of infection were more common in lower-income countries. The COVID-19 vaccination reduces the risk of SARS-CoV-2 infection (including recognized and unrecognized infections). Overweight or obesity is an independent risk factor for SARS-CoV-2 infection. Infection and lack of infection awareness are more common in lower-income countries.IMPORTANCEIn this large, international study, evidence of SARS-CoV-2 infection was obtained by testing blood specimens from 8,719 community-dwelling adults from 11 countries. The key findings are that (i) the large majority (83%) of community-dwelling adults from several high-, middle-, and low-income countries with blood test evidence of SARS-CoV-2 infection were unaware of this infection-especially in lower-income countries; and (ii) overweight/obesity predisposes to SARS-CoV-2 infection, while COVID-19 vaccination is associated with a reduced risk of SARS-CoV-2 infection. These observations are not attributable to other individual characteristics, highlighting the importance of the COVID-19 vaccination to prevent not only severe infection but possibly any infection. Further research is needed to understand the mechanisms by which overweight/obesity might increase the risk of SARS-CoV-2 infection.