Details

Autor(en) / Beteiligte

• Xue, Xiaowei
• Li, Junlai
• Wan, Wenbo
• Shi, Xianquan
• Zheng, Yiqiong

Titel

Kindlin-2 could influence breast nodule elasticity and improve lymph node metastasis in invasive breast cancer

Ist Teil von

• Scientific reports, 2017-07, Vol.7 (1), p.6753-10, Article 6753

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2017

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• This study investigated the relationship between quantitative parameters of shear wave elastography (SWE, maximum elasticity [Emax], minimum elasticity [Emin], mean elasticity [Emean]), collagen intensity and Kindlin-2 expression in benign and malignant breast nodules, and if Kindlin-2 expression is related with lymph node metastasis. A total of 102 breast nodules from 102 patients were included in our study who underwent ultrasound elastography before surgery or core needle biopsy. There was a significant difference between benign and malignant breast nodules in Emax, Emean, collagen intensity and Kindlin-2 expression, but it had no difference in Emin. Collagen intensity and Kindlin-2 expression both correlated positively with Emax, but not with Emean. Among 38 malignant breast nodules, the average Emax of the metastasis group was higher than that of the non-metastasis group, but it had no statistical significance. Compared with the non-metastasis group, Kindlin-2 expression was considerably higher in the metastasis group. However, there was no difference in collagen intensity between the metastasis group and the non-metastasis group. In conclusion, Kindlin-2 and collagen might contribute to breast nodule elasticity through molecular mechanisms. In breast cancer, overexpression of Kindlin-2 might be a risk factor for lymph node metastasis.