Details

Autor(en) / Beteiligte

• Shin, Minna
• Kang, Hyangju
• Shin, Kyeong ryeol
• Lee, Rangyeon
• Kim, Kiju
• Min, Kyungmin
• Cho, Kyou-Nam
• Sohn, Eun-Ju
• Kim, Kwang Sung
• Kim, Seok-Hyun
• Cho, Yang Je
• Park, Jeongho
• Hahn, Tae-Wook

Titel

Plant-expressed Zika virus envelope protein elicited protective immunity against the Zika virus in immunocompetent mice

Ist Teil von

• Scientific reports, 2023-12, Vol.13 (1), p.22955-22955, Article 22955

Ort / Verlag

London: Nature Publishing Group UK

Erscheinungsjahr

2023

Quelle

MEDLINE

Beschreibungen/Notizen

• Zika virus infection causes multiple clinical issues, including Guillain–Barré syndrome and neonatal malformation. Vaccination is considered as the only strategy for the prevention of ZIKV-induced clinical issues. This study developed a plant-based recombinant vaccine that transiently expressed the ZIKV envelope protein (ZikaEnv:aghFc) in Nicotiana benthamiana and evaluated the protective immunity afforded by it in immunocompetent mice. ZikaEnv:aghFc induced both humoral and cellular immunity at a low dose (1–5 μg). This immune-inducing potential was enhanced further when adjuvanted CIA09A. In addition, antigen-specific antibodies and neutralizing antibodies were vertically transferred from immunized females to their progeny and afforded both protective immunity to ZIKV and cross-protection to Dengue virus infection. These results suggest that our plant-based ZIKV vaccine provides a safe and efficient protective strategy with a competitive edge.