Nature communications, 2019-08, Vol.10 (1), p.3561-11, Article 3561
2019
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Details
- Autor(en) / Beteiligte
- Titel
- Brain-targeted drug delivery by manipulating protein corona functions
- Ist Teil von
- Nature communications, 2019-08, Vol.10 (1), p.3561-11, Article 3561
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- Protein corona presents a major obstacle to bench-to-bedside translation of targeted drug delivery systems, severely affecting targeting yields and directing unfavorable biodistribution. Corona-mediated targeting provides a new impetus for specific drug delivery by precisely manipulating interaction modes of functional plasma proteins on nano-surface. Here bio-inspired liposomes (SP-sLip) were developed by modifying liposomal surface with a short nontoxic peptide derived from Aβ that specifically interacts with the lipid-binding domain of exchangeable apolipoproteins. SP-sLip absorb plasma apolipoproteins A1, E and J, consequently exposing receptor-binding domain of apolipoproteins to achieve brain-targeted delivery. Doxorubicin loaded SP-sLip (SP-sLip/DOX) show significant enhancement of brain distribution and anti-brain cancer effect in comparison to doxorubicin loaded plain liposomes. SP-sLip preserve functions of the absorbed human plasma ApoE, and the corona-mediated targeting strategy works in SP modified PLGA nanoparticles. The present study may pave a new avenue to facilitate clinical translation of targeted drug delivery systems.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-019-11593-zTitel-ID: cdi_doaj_primary_oai_doaj_org_article_b1ea7b0d338d4e65ab52310d8be62181
- Format
- –
- Schlagworte
- Amyloid beta-Peptides - chemistry, Amyloid beta-Peptides - metabolism, Animals, Apolipoprotein E, Apolipoproteins, Apolipoproteins E - metabolism, Binding, Blood plasma, Brain, Brain - metabolism, Brain Neoplasms - drug therapy, Brain Neoplasms - pathology, Cell Line, Tumor, Doxorubicin, Doxorubicin - administration & dosage, Doxorubicin - pharmacokinetics, Drug delivery, Drug delivery systems, Humans, Lipids, Liposomes, Male, Mice, Nanoparticles, Nanoparticles - chemistry, Nanoparticles - metabolism, Peptide Fragments - chemistry, Peptide Fragments - metabolism, Plasma proteins, Polylactide-co-glycolide, Protein Corona - metabolism, Protein Interaction Domains and Motifs, Proteins, Rats, Slip, Tissue Distribution, Transdermal medication, Translation, Xenograft Model Antitumor Assays