Details

Autor(en) / Beteiligte

• Yu, Jie
• Liu, Sha
• Wang, Yupeng
• He, Xidong
• Zhang, Qingfei
• Qi, Yanxin
• Zhou, Dongfang
• Xie, Zhigang
• Li, Xiaoyuan
• Huang, Yubin

Titel

Synergistic enhancement of immunological responses triggered by hyperthermia sensitive Pt NPs via NIR laser to inhibit cancer relapse and metastasis

Ist Teil von

• Bioactive materials, 2022-01, Vol.7, p.389-400

Ort / Verlag

Elsevier B.V

Erscheinungsjahr

2022

Link zum Volltext

Quelle

Alma/SFX Local Collection

Beschreibungen/Notizen

• The combination of tumor ablation and immunotherapy is a promising strategy against tumor relapse and metastasis. Photothermal therapy (PTT) triggers the release of tumor-specific antigens and damage associated molecular patterns (DAMPs) in-situ. However, the immunosuppressive tumor microenvironment restrains the activity of the effector immune cells. Therefore, systematic immunomodulation is critical to stimulate the tumor microenvironment and augment the anti-tumor therapeutic effect. To this end, polyethylene glycol (PEG)-stabilized platinum (Pt) nanoparticles (Pt NPs) conjugated with a PD-L1 inhibitor (BMS-1) through a thermo-sensitive linkage were constructed. Upon near-infrared (NIR) exposure, BMS-1 was released and maleimide (Mal) was exposed on the surface of Pt NPs, which captured the antigens released from the ablated tumor cells, resulting in the enhanced antigen internalization and presentation. In addition, the Pt NPs acted as immune adjuvants by stimulating dendritic cells (DCs) maturation. Furthermore, BMS-1 relieved T cell exhaustion and induced the infiltration of effector T cells into the tumor tissues. Thus, Pt NPs can ablate tumors through PTT, and augment the anti-tumor immune response through enhanced antigen presentation and T cells infiltration, thereby preventing tumor relapse and metastasis. [Display omitted] •Pt NPs ablated tumor cells through PTT and served as immune adjuvants.•Released BMS-1 and deprotected maleimide by thermo-sensitive Diels-Alder reaction.•Pt NPs captured the antigens with exposed maleimide and stimulated dendritic cells maturation.•Controlled release of BMS-1 in response to PTT relieved T cell exhaustion.