Nature communications, 2019-01, Vol.10 (1), p.311-311, Article 311
2019
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- Autor(en) / Beteiligte
- Titel
- Regulation of substrate utilization and adiposity by Agrp neurons
- Ist Teil von
- Nature communications, 2019-01, Vol.10 (1), p.311-311, Article 311
- Ort / Verlag
- England: Nature Publishing Group
- Erscheinungsjahr
- 2019
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The type of nutrient utilized by the organism at any given time-substrate utilization-is a critical component of energy metabolism. The neuronal mechanisms involved in the regulation of substrate utilization in mammals are largely unknown. Here, we found that activation of hypothalamic Agrp neurons rapidly altered whole-body substrate utilization, increasing carbohydrate utilization, while decreasing fat utilization. These metabolic changes occurred even in the absence of caloric ingestion and were coupled to increased lipogenesis. Accordingly, inhibition of fatty acid synthase-a key enzyme that mediates lipogenesis-blunted the effects of Agrp neuron activation on substrate utilization. In pair-fed conditions during positive energy balance, activation of Agrp neurons improved metabolic efficiency, and increased weight gain and adiposity. Conversely, ablation of Agrp neurons impaired fat mass accumulation. These results suggest Agrp neurons regulate substrate utilization, contributing to lipogenesis and fat mass accumulation during positive energy balance.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 2041-1723eISSN: 2041-1723DOI: 10.1038/s41467-018-08239-xTitel-ID: cdi_doaj_primary_oai_doaj_org_article_aec5a3d86db84795ba57c26be1d58b35
- Format
- –
- Schlagworte
- Ablation, Accumulation, Adipose tissue, Adiposity - physiology, Agouti-Related Protein - metabolism, Animals, Body fat, Body weight gain, Capsaicin - pharmacology, Carbohydrate Metabolism, Carbohydrates, Critical components, Energy balance, Energy conversion efficiency, Energy metabolism, Energy Metabolism - physiology, Fatty acids, Fatty-acid synthase, Hypothalamus, Hypothalamus - metabolism, Ingestion, Lipogenesis, Lipogenesis - physiology, Metabolism, Mice, Mice, Knockout, Neurons, Neurons - drug effects, Neurons - metabolism, Nutrient utilization, Oxidation, Substrates, Utilization, Weight Gain - physiology