Details

Autor(en) / Beteiligte

• García-Moreno, Fernando
• Anderton, Edward
• Jankowska, Marta
• Begbie, Jo
• Encinas, Juan Manuel
• Irimia, Manuel
• Molnár, Zoltán

Titel

Absence of Tangentially Migrating Glutamatergic Neurons in the Developing Avian Brain

Ist Teil von

• Cell reports (Cambridge), 2018-01, Vol.22 (1), p.96-109

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2018

Link zum Volltext

Quelle

EZB-FREE-00999 freely available EZB journals

Beschreibungen/Notizen

• Several neuronal populations orchestrate neocortical development during mammalian embryogenesis. These include the glutamatergic subplate-, Cajal-Retzius-, and ventral pallium-derived populations, which coordinate cortical wiring, migration, and proliferation, respectively. These transient populations are primarily derived from other non-cortical pallial sources that migrate to the dorsal pallium. Are these migrations to the dorsal pallium conserved in amniotes or are they specific to mammals? Using in ovo electroporation, we traced the entire lineage of defined chick telencephalic progenitors. We found that several pallial sources that produce tangential migratory neurons in mammals only produced radially migrating neurons in the avian brain. Moreover, ectopic expression of VP-specific mammalian Dbx1 in avian brains altered neurogenesis but did not convert the migration into a mammal-like tangential movement. Together, these data indicate that tangential cellular contributions of glutamatergic neurons originate from outside the dorsal pallium and that pallial Dbx1 expression may underlie the generation of the mammalian neocortex during evolution. [Display omitted] •Lack of tangential migration of Cajal-Retzius and subplate cells in chick•No intra-pallial tangential migrations contribute to the dorsal pallium in chick•Mammalian Dbx1 promotes differentiative divisions in chick ventral pallium•Unique tangential migrations could have played a major role in cortical evolution Neocortical formation crucially depends on the early tangential arrival of several transient glutamatergic neuronal populations. García-Moreno et al. find that these neuronal migrations are absent in the developing brain of chicks. The mammalian uniqueness of these developing migrations suggests a crucial role of these cells in the evolutionary origin of the neocortex.