BMC research notes, 2019-09, Vol.12 (1), p.584-584, Article 584
2019
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- Autor(en) / Beteiligte
- Titel
- Comparison of four pharmacological strategies aimed to prevent the lung inflammation and paraquat-induced alveolar damage
- Ist Teil von
- BMC research notes, 2019-09, Vol.12 (1), p.584-584, Article 584
- Ort / Verlag
- England: BioMed Central Ltd
- Erscheinungsjahr
- 2019
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The aim of this study was to compare in vivo effect of five pharmacological options on inflammation and pulmonary fibrosis induced by paraquat. 54 Wistar SPF rats were used. After 2 h post-intoxication with paraquat ion, groups of 9 animals were randomly assigned to (1) cyclophosphamide plus dexamethasone (2) low molecular weight heparin (3) unfractionated heparin (4) vitamin C every 24 h, (5) atorvastatin or (6) placebo with intraperitoneal saline. Lung inflammation, alveolar injury, hepatocyte damage, hepatic regeneration, acute tubular necrosis and kidney congestion were evaluated. In the control group 100% of animals presented moderate and severe lung inflammation, while in the groups with atorvastatin and intratracheal heparin this proportion was lower (55.5%; CI 26.6-81.3%) (p = 0.025). A lower degree of moderate or severe hepatic regeneration was evident in the treatment groups with atorvastatin (p = 0.009). In this study was demonstrated that statins and heparin might have a protective effect in the paraquat-induced destructive phase. More evidence is needed to evaluated of dose-response effects of these drugs before to study in clinical trials.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1756-0500eISSN: 1756-0500DOI: 10.1186/s13104-019-4598-0Titel-ID: cdi_doaj_primary_oai_doaj_org_article_adce646e2a6942c69af315cb9ec1b7be
- Format
- –
- Schlagworte
- Alveoli, Animals, Antioxidants, Antioxidants - pharmacology, Ascorbic acid, Ascorbic Acid - pharmacology, Atorvastatin, Atorvastatin - pharmacology, Care and treatment, Clinical trials, Complications and side effects, Cyclophosphamide, Cyclophosphamide - pharmacology, Dexamethasone, Dexamethasone - pharmacology, Drug Therapy - methods, Drug Therapy, Combination, Edema, Fibrosis, Heparin, Heparin - pharmacology, Heparin, Low-Molecular-Weight - pharmacology, Inflammation, Intoxication, Kidneys, Liver, Lung, Lung - drug effects, Lung - pathology, Lung diseases, Molecular weight, Paraquat, Paraquat - toxicity, Pneumonia - drug therapy, Pneumonia - pathology, Poisoning, Prevention, Pulmonary Alveoli - drug effects, Pulmonary Alveoli - pathology, Pulmonary fibrosis, Pulmonary Fibrosis - chemically induced, Pulmonary Fibrosis - drug therapy, Rats, Wistar, Research Note, Statins, Trachea, Treatment Outcome