Details

Autor(en) / Beteiligte

• Grados, Marco A
• Atkins, Elizabeth B
• Kovacikova, Gabriela I
• McVicar, Erin

Titel

A selective review of glutamate pharmacological therapy in obsessive-compulsive and related disorders

Ist Teil von

• Psychology Research and Behavior Management, 2015-01, Vol.8 (default), p.115-131

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2015

Link zum Volltext

Quelle

EZB Electronic Journals Library

Beschreibungen/Notizen

• Glutamate, an excitatory central nervous system neurotransmitter, is emerging as a potential alternative pharmacological treatment when compared to gamma-aminobutyric acid (GABA)-, dopamine-, and serotonin-modulating treatments for neuropsychiatric conditions. The pathophysiology, animal models, and clinical trials of glutamate modulation are explored in disorders with underlying inhibitory deficits (cognitive, motor, behavioral) including obsessive-compulsive disorder, attention deficit hyperactivity disorder, Tourette syndrome, trichotillomania, excoriation disorder, and nail biting. Obsessive-compulsive disorder, attention deficit hyperactivity disorder, and grooming disorders (trichotillomania and excoriation disorder) have emerging positive data, although only scarce controlled trials are available. The evidence is less supportive for the use of glutamate modulators in Tourette syndrome. Glutamate-modulating agents show promise in the treatment of disorders of inhibition.