Details

Autor(en) / Beteiligte

• Azoulay, Daniel
• Feray, Cyrille
• Lim, Chetana
• Salloum, Chady
• Conticchio, Maria
• Cherqui, Daniel
• Sa Cunha, Antonio
• Adam, René
• Vibert, Eric
• Samuel, Didier
• Allard, Marc Antoine
• Golse, Nicolas

Titel

A systematic review of auxiliary liver transplantation of small-for-size grafts in patients with chronic liver disease

Ist Teil von

• JHEP reports, 2022-04, Vol.4 (4), p.100447-100447, Article 100447

Ort / Verlag

Netherlands: Elsevier B.V

Erscheinungsjahr

2022

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• The shortage of liver grafts continues to worsen. Because the expanded use of small-for-size grafts (SFSGs) would substantially alleviate this shortage, we aimed to analyse the available knowledge on auxiliary liver transplantation (ALT) with SFSGs in patients with chronic liver disease (CLD) to identify opportunities to develop ALT with SFSGs in patients with CLD. This is a systematic review on ALT using SFSGs in patients with CLD. The review was completed by updates obtained from the authors of the retained reports. Heterotopic ALT was performed in 26 cases between 1980 and 2017, none for SFGS stricto sensu, and auxiliary partial orthotopic liver transplantation (APOLT) in 27 cases (from 1999 to 2021), all for SFSG. In APOLT cases, partial native liver resection was performed in most of cases, whereas the second-stage remnant native liver hepatectomy was performed in 9 cases only. The median graft-to-body weight ratio was 0.55, requiring perioperative or intraoperative portal modulation in 16 cases. At least 1 complication occurred in 24 patients following the transplant procedure (morbidity rate, 89%). Four patients (4/27, 15%) died after the APOLT procedure. At the long term, 19 (70%) patients were alive and well at 13 months to 24 years (median, 4.5 years) including 18 with the APOLT graft in place and 1 following retransplantation. Despite high postoperative morbidity, and highly reported technical variability, the APOLT technique is a promising technique to use SFSGs in patients with CLD, achieving satisfactory long-term results. The results need to be confirmed on a larger scale, and a standardised technique could lead to even better results. At the cost of a high postoperative morbidity, the long-term results of APOLT for small-for-size grafts are good. Standardisation of the procedure and of portal modulation remain needed. [Display omitted] •Using a small-for-size graft is a risk factor of small-for-size syndrome.•Auxiliary liver transplantation can be orthotopic or heterotopic.•In auxiliary transplantation, the remnant native liver prevents small-for-size syndrome.•Transplantation with a small-for-size graft requires individually tailored portal modulation.•Auxiliary liver transplantation might substantially increase the number of available grafts.