Details

Autor(en) / Beteiligte

• Guo, Li-Na
• Yu, Shu-Ying
• Xiao, Meng
• Yang, Chun-Xia
• Bao, Chun-Mei
• Yu, Yan-Hua
• Ye, Li-Yan
• Yang, Yang
• Zhang, Ge
• Liu, Jie
• Liang, Guo-Wei
• Min, Rong
• Zhu, Yu
• Lei, Hong
• Liu, Yu-Lei
• Liu, Lin-Juan
• Hu, Yun-Jian
• Hsueh, Po-Ren
• Xu, Ying-Chun

Titel

Species Distribution and Antifungal Susceptibility of Invasive Candidiasis: A 2016-2017 Multicenter Surveillance Study in Beijing, China

Ist Teil von

• Infection and drug resistance, 2020-01, Vol.13, p.2443-2452

Ort / Verlag

New Zealand: Dove Medical Press Limited

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Invasive candidiasis (IC), a life-threatening fungal infection prevalent among hospitalized patients, has highly variable regional epidemiology. We conducted a multicenter surveillance study to investigate recent trends in species distribution and antifungal susceptibility patterns among IC-associated spp. in Beijing, China, from 2016 to 2017. A total of 1496 non-duplicate isolates, recovered from blood and other sterile body fluids of IC patients, were identified using matrix-assisted laser desorption/ionization time of flight mass spectrometry combined with ribosomal DNA internal transcribed spacer (ITS) region sequencing. Broth microdilution-based susceptibility testing using six antifungal agents was also conducted. was the most frequently isolated species (49.9%), followed by (15.5%), (14.7%) and (14.2%). No significant differences in species distribution were observed when compared with a 2012-2013 dataset. Overall, the rates of susceptibility to fluconazole and voriconazole were high among (98% and 97.2%, respectively) and species complex (91.1% and 92%, respectively) isolates but low among (81.5% and 81.1%, respectively) isolates. In addition, the rate of azole resistance among isolates increased significantly (1.8-fold, <0.05) compared with that observed in 2012-2013, while micafungin resistance rates were <5% for all tested species. Our results suggest that species distribution has remained stable among IC-associated isolates in Beijing. Resistance to micafungin was rare, but increased azole resistance among isolates was noted. Our study provides information on local epidemiology that will be important for the selection of empirical antifungal agents and contributes to global assessments of antifungal resistance.