Details

Autor(en) / Beteiligte

• Ito, Takeshi
• Kawai, Yohei
• Yasui, Yutaka
• Iriguchi, Shoichi
• Minagawa, Atsutaka
• Ishii, Tomoko
• Miyoshi, Hiroyuki
• Taketo, M Mark
• Kawada, Kenji
• Obama, Kazutaka
• Sakai, Yoshiharu
• Kaneko, Shin

Titel

The therapeutic potential of multiclonal tumoricidal T cells derived from tumor infiltrating lymphocyte-1derived iPS cells

Ist Teil von

• Communications biology, 2021-06, Vol.4 (1), p.694-694

Ort / Verlag

England: Nature Portfolio

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Tumor-infiltrating lymphocytes (TIL), which include tumor-specific T lymphocytes with frequency, are used for adoptive cell transfer therapy (ACT) in clinical practice. The optimization of TIL preparation has been investigated to reduce the senescence and increase the abundance of TIL, as both the quality and quantity of the transferred cells have great influence on the outcome of TIL-based ACT (TIL-ACT). Considering the effects of cell reprogramming on senescence, we expected that the anti-tumor effect could be enhanced by TIL regeneration. To confirm this hypothesis, we established tumor-specific TIL-derived iPS cells (TIL-iPSC) with human colorectal cancer specimens. T cells differentiated from TIL-iPSC (TIL-iPS-T) retained not only intrinsic T cell functions and tumor specificity, but also exhibited improved proliferation capacity and additional killing activity. Moreover, less differentiated profiles and prolonged persistency were seen in TIL-iPS-T compared with primary cells. Our findings imply that iPSC technology has great potential for TIL-ACT.