Details

Autor(en) / Beteiligte

• Xu, Meng
• Wang, Dan
• Wang, Hongye
• Zhang, Xiaomei
• Liang, Te
• Dai, Jiayu
• Li, Meng
• Zhang, Jiahui
• Zhang, Kai
• Xu, Danke
• Yu, Xiaobo

Titel

COVID‐19 diagnostic testing: Technology perspective

Ist Teil von

• Clinical and translational medicine, 2020-08, Vol.10 (4), p.e158-n/a

Ort / Verlag

United States: John Wiley and Sons Inc

Erscheinungsjahr

2020

Link zum Volltext

Quelle

Wiley Online Library

Beschreibungen/Notizen

• The corona virus disease 2019 (COVID‐19) is a highly contagious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2). More than 18 million people were infected with a total of 0.7 million deaths in ∼188 countries. Controlling the spread of SARS‐CoV‐2 is therefore inherently dependent on identifying and isolating infected individuals, especially since COVID‐19 can result in little to no symptoms. Here, we provide a comprehensive review of the different primary technologies used to test for COVID‐19 infection, discuss the advantages and disadvantages of each technology, and highlight the studies that have employed them. We also describe technologies that have the potential to accelerate SARS‐CoV‐2 detection in the future, including digital PCR, CRISPR, and microarray. Finally, remaining challenges in COVID‐19 diagnostic testing are discussed, including (a) the lack of universal standards for diagnostic testing; (b) the identification of appropriate sample collection site(s); (c) the difficulty in performing large population screening; and (d) the limited understanding of SARS‐COV‐2 viral invasion, replication, and transmission. A comprehensive review of the different primary technologies used to test for COVID‐19 infection. The review indicates the advantages and disadvantages of each technology, describes technologies that have the potential to accelerate SARS‐CoV‐2 detection in the future, and discusses the remaining challenges in COVID‐19 diagnostic testing.