Details

Autor(en) / Beteiligte

• Mellbin, Astrid
• Rongala, Udaya
• Jörntell, Henrik
• Bengtsson, Fredrik

Titel

ECoG activity distribution patterns detects global cortical responses following weak tactile inputs

Ist Teil von

• iScience, 2024-04, Vol.27 (4), p.109338-109338, Article 109338

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

2024

Link zum Volltext

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Many studies have suggested that the neocortex operates as a global network of functionally interconnected neurons, indicating that any sensory input could shift activity distributions across the whole brain. A tool assessing the activity distribution across cortical regions with high temporal resolution could then potentially detect subtle changes that may pass unnoticed in regionalized analyses. We used eight-channel, distributed electrocorticogram (ECoG) recordings to analyze changes in global activity distribution caused by single pulse electrical stimulations of the paw. We analyzed the temporally evolving patterns of the activity distributions using principal component analysis (PCA). We found that the localized tactile stimulation caused clearly measurable changes in global ECoG activity distribution. These changes in signal activity distribution patterns were detectable across a small number of ECoG channels, even when excluding the somatosensory cortex, suggesting that the method has high sensitivity, potentially making it applicable to human electroencephalography (EEG) for detection of pathological changes. [Display omitted] •Weak tactile stimulation cause a global shift in the ECoG activity distribution•Results were not dependent on the tactile stimulation evoking a detectable response•This could be used to detect small perturbations in cortical processing•Might be a method to monitor disease-related changes in human EEG activity Neuroscience; Sensory neuroscience; Cognitive neuroscience