Details

Autor(en) / Beteiligte

• Bauer, Marcus
• Vaxevanis, Christoforos
• Al-Ali, Haifa Kathrin
• Jaekel, Nadja
• Naumann, Christin Le Hoa
• Schaffrath, Judith
• Rau, Achim
• Seliger, Barbara
• Wickenhauser, Claudia

Titel

Altered Spatial Composition of the Immune Cell Repertoire in Association to CD34 + Blasts in Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemia

Ist Teil von

• Cancers, 2021-01, Vol.13 (2), p.186

Ort / Verlag

Switzerland: MDPI AG

Erscheinungsjahr

2021

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• : Myelodysplastic syndromes (MDS) are caused by a stem cell failure and often include a dysfunction of the immune system. However, the relationship between spatial immune cell distribution within the bone marrow (BM), in relation to genetic features and the course of disease has not been analyzed in detail. : Histotopography of immune cell subpopulations and their spatial distribution to CD34 hematopoietic cells was determined by multispectral imaging (MSI) in 147 BM biopsies (BMB) from patients with MDS, secondary acute myeloid leukemia (sAML), and controls. : In MDS and sAML samples, a high inter-tumoral immune cell heterogeneity in spatial proximity to CD34 blasts was found that was independent of genetic alterations, but correlated to blast counts. In controls, no CD8 and FOXP3 T cells and only single MUM1p B/plasma cells were detected in an area of ≤10 μm to CD34 HSPC. : CD8 and FOXP3 T cells are regularly seen in the 10 μm area around CD34 blasts in MDS/sAML regardless of the course of the disease but lack in the surrounding of CD34 HSPC in control samples. In addition, the frequencies of immune cell subsets in MDS and sAML BMB differ when compared to control BMB providing novel insights in immune deregulation.