Details

Autor(en) / Beteiligte

• Freire, Marco Aurélio M
• Santos, José Ronaldo

Titel

Parkinson's disease: general features, effects of levodopa treatment and future directions

Ist Teil von

• Frontiers in neuroanatomy, 2010-11, Vol.4, p.146-146

Ort / Verlag

Switzerland: Frontiers Research Foundation

Erscheinungsjahr

2010

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Following the neuronal degeneration there is a loss of the striatal dopaminergic innervation, which ultimately results in the characteristic motor dysfunction observed in PD. In addition to the motor dysfunction, cognitive, and behavioral alterations are also observed in PD, since other neuronal groups are affected for instance in the locus coeruleus, the nucleus basalis of Meynert, and in later stages, in the neocortex (Braak et al., 2003). The authors cite positron emission tomography (PET) and single photon emission computed tomography (SPECT) as tools capable of provide important information regarding the events underlying the appearing/progression of the PD. In addition, animal models reproducing neuropathological/behavioral aspects of PD also are important to a better understanding of the alterations observed during this disease. [...]more studies emphasizing not only the motor deficits but also the alterations observed in areas associative and related to cognition can provide a more comprehensive understanding of PD, especially correlated to the development of more effective drugs to reduce the disturbs observed in this pathology or even to a better understanding concerning the action of drugs already known.