Details

Autor(en) / Beteiligte

• Ma, Xiang
• Liu, Lesen
• Sun, Jing
• Zhang, Yun
• Liu, Yanqin
• Liu, Miao
• Wang, Bing
• Chang, Yuna
• Han, Yuling
• Gai, Zhongtao

Titel

Expression of circulating angiotensin‐converting enzyme 2 in children with asthma and the effects of inhaled corticosteroids

Ist Teil von

• Immunity, Inflammation and Disease, 2023-07, Vol.11 (7), p.e922-n/a

Ort / Verlag

England: John Wiley & Sons, Inc

Erscheinungsjahr

2023

Link zum Volltext

Quelle

Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals

Beschreibungen/Notizen

• Background The global spread of coronavirus disease 2019 (COVID‐19) has resulted in a significant disease burden, yet asthma patients do not have the expected high morbidity and mortality rates in the pandemics of COVID‐19. Objective To find the difference of angiotensin‐converting enzyme 2 (ACE2) in asthma and nonasthma children and evaluate the effect of inhaled corticosteroids (ICS) on its expression. Methods The ACE2, immunoglobulin E (IgE), and eosinophils were tested in different children. Results A total of 157 children aged 3–16 years were enrolled. The expression of ACE2 in asthma children were lower than nonasthma children (T = −2.512, p = .013). Allergic nonasthma children had a significant higher ACE2 expression than children with allergic asthma (p = .013) and nonallergic asthma (p = .029). The expression of ACE2 had no significant difference between first‐diagnosed asthma children and that had been treated with ICS for ≥6 months (F = 0.028, p = .598). The allergic asthma children showed a significantly higher eosinophils cells (EC) count than the allergic nonasthma (W = 200, p < .001) and nonallergic nonasthma children (W = 1089, p < .001). Nonallergic asthma children also had a significant higher EC count than the allergic non‐asthma (W = 182.5, p < .001) and nonallergic non‐asthma (W = 200.5, p < .001) children. There was no significant difference in IgE levels between asthmatic children and non‐asthmatic children (W = 2792.5, p = .18). Conclusion Circulating ACE2 levels in asthmatic children were lower than those in non‐asthmatic children and ICS treatment for ≥6 months did not affect the expression of ACE2 in peripheral blood in the asthma children. Key Points In the present study, we analyze the expression of circulating angiotensin‐converting enzyme 2 in asthmatic children and the effects of inhaled corticosteroids. And we found that the children with asthma had lower ACE2 level than no‐asthmatic children. Furthermore, there were no significant difference between the asthmatic children with or without ICS treatment. It's very helpful to get further understanding about the relationship between asthma and COVID‐19 in children.